Description
An N-glycosyl compound that is cytosine in which the proton at position 1 is replaced by a beta-D-glucuronosyl residue.
Chemical properties
| Chemical formula | Net charge | Average mass |
|---|---|---|
| C10H13N3O7 | 0 | 287.227 |
Nomenclature
| IUPAC | SMILES | InChI | InChIKey | Synonyms |
|---|---|---|---|---|
| 4-amino-1-beta-D-glucopyranuronosylpyrimidin-2(1H)-one | O1[C@H](C(O)=O)[C@H]([C@H](O)[C@H]([C@@H]1N2C=CC(=NC2=O)N)O)O | InChI=1S/C10H13N3O7/c11-3-1-2-13(10(19)12-3)8-6(16)4(14)5(15)7(20-8)9(17)18/h1-2,4-8,14-16H,(H,17,18)(H2,11,12,19)/t4-,5-,6+,7-,8+/m0/s1 | CHKIQPXDGYGCHW-YOWKYNACSA-N |
|
Citations
- Cone, MC, et al. 1998. Cloning and heterologous expression of blasticidin S biosynthetic genes from Streptomyces griseochromogenes. The Journal of Antibiotics. 51(6).
- Feng, J, et al. 2013. Discovery and characterization of BlsE, a radical S-adenosyl-L-methionine decarboxylase involved in the blasticidin S biosynthetic pathway. PloS One. 8(7).
- Gould, SJ, et al. 1995. Cytosinine: pyridoxal phosphate tautomerase, a new enzyme in the blasticidin S biosynthetic pathway. The Journal of Antibiotics. 48(7).
- Gould, SJ, et al. 1994. Cytosylglucuronic acid synthase (cytosine: UDP-glucuronosyltransferase) from Streptomyces griseochromogenes, the first prokaryotic UDP-glucuronosyltransferase. Journal of Bacteriology. 176(5).
- Li, L, et al. 2013. Streptomyces lividans blasticidin S deaminase and its application in engineering a blasticidin S-producing strain for ease of genetic manipulation. Applied and Environmental Microbiology. 79(7).
- Seto, H, et al. 1976. Studies on the biosynthesis of blasticidin S. V. Isolation and structure of pentopyranic acid. The Journal of Antibiotics. 29(5).
- Wu, J, et al. 2012. Analysis of the mildiomycin biosynthesis gene cluster in Streptoverticillum remofaciens ZJU5119 and characterization of MilC, a hydroxymethyl cytosyl-glucuronic acid synthase. Chembiochem : A European Journal of Chemical Biology. 13(11).